Titlebook: Bone Drugs in Pediatrics; Efficacy and Challen Gordon L. Klein Book 2014 Springer Science+Business Media New York 2014 Anti-resorptive.Bisp

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Book 2014dren, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how

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Siegfried B?hme,Walter Fricke,Gert Zechrevent or treat pediatric bone loss. Even though no drugs have current approval for this purpose from the United States Food and Drug Administration (FDA), these chapters contain evidence of both safety and efficacy of antiresorptive and anabolic medications that have been used off-label in a variety of pediatric conditions.

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Periodicals, Proceedings, Books, Activities,shown to decrease bone pain, enhance well-being and improve mobility and muscle strength, in addition to reducing the incidence of fractures. This chapter summarises the historical use, safety and efficacy of bisphosphonate therapy in children and adolescents with OI.

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Introduction,hild suffers from a genetic condition in which bone loss is flagrant the process of bone loss is often asymptomatic and if it occurs consequent to an underlying condition it does not attract medical attention. Therefore, this book undertakes to call to the reader’s attention the drugs available to p

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Developmental Pharmacokinetics: Drug Disposition Relative to Age,’s systemic circulation, distribute to its site of action, and bind to target receptors for a sufficient time period to realize these effects. A drug’s sojourn in the body, i.e., absorption, distribution, metabolism, and elimination, is described by the drug’s pharmacokinetic profile. The optimal, a

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