Titlebook: Blood Substitutes and Oxygen Biotherapeutics; Henry Liu,Alan D. Kaye,Jonathan S. Jahr Book 2022 The Editor(s) (if applicable) and The Auth

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https://doi.org/10.1007/978-3-030-27103-9 and more recently, HBOC oxygen carrier with enhancement of both antioxidant and CO. transport functions. The early complete artificial cell were developed into PEG-lipid membrane and PEG-polylactide nano-dimension artificial rbc.

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Reflection, Mirrors, and Kaleidoscopes,ficial or cultured erythrocytes. Erythrocyte substitutes can also be classified based on the source of hemoglobin, existence of cell membrane, and organic or inorganic oxygen carriers. Almost a century’s pursuit yielded only few products with limited clinical use in limited regions frustrated many b

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https://doi.org/10.1007/b138587tion secondary to the abluminal and luminal nitric oxide scavenging actions by the free hemoglobin molecules is postulated to be an underlying pathophysiology contributing to possible hypertension, reduced oxygen delivery and organ ischemia. Although HBOC manufacturers have attempted with great effo

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Masayoshi Nakasako,Satoru Tokutomised in most commonly manufactured HBOCs unfortunately enhance Hb oxidative side reactions leading to compromised safety profiles. A lot has been learned from investigating aged, diseased RBCs, and naturally occurring mutant Hbs in vitro, as well as in animal and human studies. As a result, alternati

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Masayoshi Nakasako,Satoru Tokutomirfluorooctyll bromide, (3) tertbutylperfluorocyclohexane, (4) dodecafluoropentane, and (5) perftoran. When combined with other blood-saving strategies, the use of perfluorocarbon-based oxygen carriers enables the performance of surgical procedures with increased blood loss while eliminating or lower

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