Titlebook: Blood Pressure Disorders in Diabetes Mellitus; Adel E. Berbari,Giuseppe Mancia Book 2023 Springer Nature Switzerland AG 2023 Diabetic hype

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978-3-031-13011-3Springer Nature Switzerland AG 2023

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Hypertension and Type 2 Diabetesuences. The main driving mechanisms of this association are maladaptive endothelial dysfunction, renin-angiotensin-aldosterone system (RAAS) and sympathetic overactivity, abnormal sodium handling, renal dysfunction, and vascular stiffness. Blood pressure (BP) elevation in T2DM has a characteristic p

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Office/Out-of-Office Blood Pressure Measurementsion-induced organ damage and the risk of major cardiovascular complications and mortality, emerging from studies conducted in mixed cohorts of diabetic and nondiabetic subjects, has been substantially confirmed in the specific context of diabetes. Consequently, self-measured home BP and 24-h BP moni

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Laboratory Indices/Bioimaging possibly on an annual basis. In patients with hypertension and concomitant diabetes, the risk of developing cardiovascular disease (CVD), macrovascular diseases, and/or microvascular diseases is two- to fivefold greater than in patients with either hypertension or DM. In patients with DM, the prese

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Molecular Mechanisms Underlying Vascular Disease in Diabetes in diabetes is typically associated with atherosclerosis and calcification leading to heart disease and stroke. Microvascular disease leads to retinopathy, nephropathy and neuropathy. Clinically this manifests as reduced vision and blindness, kidney dysfunction and peripheral neuropathy—major compl

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Mechanisms of Diabetic Nephropathy in Humans and Experimental Animals to the utility of experimental animal models. Pathologically, DKD is characterized by glomerular basement membrane thickening, mesangial matrix expansion, glomerulosclerosis, and tubulointerstitial fibrosis. These changes correlate clinically with the development of albuminuria and hypertension and