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Titlebook: Blood Cell Biochemistry; Hematopoiesis and Ge Leslie J. Fairbairn,Nydia G. Testa Book 1999 Kluwer Academic / Plenum Publishers 1999 HIV.bio

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發(fā)表于 2025-3-21 18:12:04 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Blood Cell Biochemistry
期刊簡稱Hematopoiesis and Ge
影響因子2023Leslie J. Fairbairn,Nydia G. Testa
視頻videohttp://file.papertrans.cn/190/189299/189299.mp4
學科分類Blood Cell Biochemistry
圖書封面Titlebook: Blood Cell Biochemistry; Hematopoiesis and Ge Leslie J. Fairbairn,Nydia G. Testa Book 1999 Kluwer Academic / Plenum Publishers 1999 HIV.bio
影響因子Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express- ing adenosine deaminase (the defective enzyme in patients with this disorder). The partial success of this treatment was perhaps responsible for undue optimism among those proposing other gene therapy treatments within the hematopoietic system, and it has since become clear that there are a number of technical and biological difficulties to overcome before hematopoietic gene therapy becomes a mainstream therapeutic strategy. The chapters in this book evaluate the need for gene therapy in the hematopoietic system, discuss how efficient gene tra
Pindex Book 1999
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1078-0491 r genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation bio
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https://doi.org/10.1057/9781137441836 of either DNA or mRNA. However, in practice there are very few RNA vaccines (., .; .), probably because expression is too shortlived to be effective. Thus, most models of nucleic acid-based immunization described to date have used DNA, most often in the form of double-stranded, closed, circular plasmid DNA.
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