Titlebook: Bleomycin: Chemical, Biochemical, and Biological Aspects; Proceedings of a joi Sidney M. Hect Conference proceedings 1979 Springer-Verlag N

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要塞

Advances in Bleomycin Studiesh bleomycin treatment and even cases of complete cure have been reported. Among the tumors belonging to this group, the well-differentiated type responds to bleomycin treatment with a very high frequency. There are patients who have lived more than 10 years after several courses of treatment with bl

Accomplish

Review of the Structural Studies on Bleomycind as a mixture of more than 10 components from the culture filtrate of .. These were separated by CM-Sephadex column chromatography. and found to be different from one another in their terminal amine moieties.. BLMs thus isolated were blue-colored equimolar copper complexes. BLM has not yet been cry

REP

責(zé)難

A Synthetic Approach to the Pyrimidine Moiety of Bleomycinrolysis, proton and .C-NMR, infrared spectra and p..′ values (1)(.). A revised structure (2) containing an open chain β-aminopropionamide group instead of the β-lactam ring has been proposed at this symposium by Dr. Takita. It should be pointed out that the new structure (2) was considered to be one

faddish

Biogenetic Aspects of Bleomycin-Phleomycin Group Antibioticsophisticated natural products containing unusual amino acids as their building blocks .; they also have interesting glycosidic moieties . and are efficient chelating agents. In addition, new members of this family have recently been isolated . . The production of various bleomycins . and phleomycins

Original

Liquid Chromatography of Bleomycinmical study of bleomycin (BLM) for the following reasons: (i) BLMs are produced as a mixture by fermentation together with their biosynthetic intermediates. To facilitate their chemical study, they have been separated into individual species by LC, (ii) BLM has many susceptible functional groups. Th

生命層

gangrene

The Metallobleomycins Of these, bleomycin A. (BLM A.) , 1., is the most abundant, accounting for 55-70% (w/w) of the mixture. Bleomycin is of value in the treatment of squamous cell carcinomas, lymphomas, and testicular carcinomas (.). The mechanism of action of bleomycin is not understood. Most of the early efforts as

resuscitation

Metal Complex of Bleomycin and Its Implication for the Mechanism of Bleomycin Action salt added to the fermentation medium; without addition of the copper, the fermentation yield of BLM is significantly reduced. The chelated copper can be removed from BLM by precipitation with hydrogen sulfide in methanol solution. Treatment of metal-free BLM with an excess of an inorganic cupric s