Titlebook: Bladder Pain Syndrome; A Guide for Clinicia J?rgen Nordling,Jean Jacques Wyndaele,Magnus Fall Book 2013 Springer Science+Business Media New

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Historical Perspective,hanges in approach to treatment that have occurred as a direct result of the paradigm change in the last 25 years. What had been considered a rare disorder that was exclusively related to bladder pathology with specific endoscopic and common pathologic findings morphed into a much more prevalent chr

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Epidemiology,variable. This is due to the inconsistency of diagnostic criteria and relative rarity of the disease and methodological problems. The questionnaires used may have good specificity and low sensitivity or vice versa. Many studies are based on institutional observations, and only few genuine population

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Clinical Pathophysiology and Molecular Biology of the Urothelium and the GAG Layerling molecules” which, through the “sensory web,” contribute to the regulation of the urinary function. The knowledge of its molecular basis is getting further details in disclosing its “complex mechanisms”; control of the latter, through a targeted therapy, represents an exciting challenge for basi

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Mast Cell and Bladder Pain Syndromeypical symptom complex. There are an abundance of theories regarding the pathogenesis. Among the numerous proposals are “l(fā)eaky epithelium,” mast cell activation, and neurogenic inflammation. Current evidence from clinical and laboratory studies confirms that mast cells play a central role in the pat

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