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Titlebook: Bispecific Antibodies; Roland E. Kontermann Book 2011 Springer-Verlag Berlin Heidelberg 2011 Cancer therapy.Hybridoma.Immunoglobulin.Immun

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發(fā)表于 2025-3-21 20:08:53 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Bispecific Antibodies
影響因子2023Roland E. Kontermann
視頻videohttp://file.papertrans.cn/189/188886/188886.mp4
發(fā)行地址Presents the recent advances in antibody engineering and in the various clinical applications.An invaluable resource for both experts and those new to the field.With contributions by international exp
圖書封面Titlebook: Bispecific Antibodies;  Roland E. Kontermann Book 2011 Springer-Verlag Berlin Heidelberg 2011 Cancer therapy.Hybridoma.Immunoglobulin.Immun
影響因子.The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy..In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed..
Pindex Book 2011
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書目名稱Bispecific Antibodies影響因子(影響力)




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沙發(fā)
發(fā)表于 2025-3-21 22:45:12 | 只看該作者
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發(fā)表于 2025-3-22 01:55:10 | 只看該作者
,Allgemeine physikalische Hilfss?tze,ill present an overview of work that have been published, including a brief introduction to the particular molecular scaffolds with the structural basis and some of the biophysical and biochemical properties before describing the bispecific application.
地板
發(fā)表于 2025-3-22 07:44:54 | 只看該作者
Die Technik der kystoskopischen Untersuchunghe biochemical and biophysical properties and the manufacturability of BsAb. This chapter reviews the current advances in design and engineering of the IgG-like BsAb in the context of their potential clinical applications.
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發(fā)表于 2025-3-22 10:36:46 | 只看該作者
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發(fā)表于 2025-3-22 14:10:46 | 只看該作者
Alternative Scaffolds as Bispecific Antibody Mimetics,ill present an overview of work that have been published, including a brief introduction to the particular molecular scaffolds with the structural basis and some of the biophysical and biochemical properties before describing the bispecific application.
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發(fā)表于 2025-3-22 20:43:37 | 只看該作者
The Design and Engineering of IgG-Like Bispecific Antibodies,he biochemical and biophysical properties and the manufacturability of BsAb. This chapter reviews the current advances in design and engineering of the IgG-like BsAb in the context of their potential clinical applications.
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發(fā)表于 2025-3-22 21:18:57 | 只看該作者
The Dock-and-Lock (DNL) Approach to Novel Bispecific Antibodies, AD module occurs spontaneously, and the resulting complex is locked with disulfide bonds to enhance in vivo stability. This new platform technology provides a versatile approach to create novel bispecific antibodies of multiple valencies, with potential applications in the detection and therapy of diverse diseases.
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發(fā)表于 2025-3-23 02:31:29 | 只看該作者
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發(fā)表于 2025-3-23 07:28:36 | 只看該作者
ose new to the field.With contributions by international exp.The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the
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