Titlebook: Biotargets of Cancer in Current Clinical Practice; Mauro Bologna Book 2012 Springer Science+Business Media, LLC 2012 Cancer Therapeutics.E

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Right Heart CatheterizationAppropriate use of right heart catheterization (RHC), is viewed as an invaluable tool for hemodynamic monitoring and management of critically ill patients with a wide spectrum of cardiopulmonary diseases and remains the “gold standard” for the diagnosis of specific conditions.

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Exercise ECG Stress TestingExercise ECG testing (ET) is a well-validated procedure for the diagnosis of coronary artery disease (CAD) and to assess prognosis. This test is simple and easy to perform the test, with minimal equipment required. Obviously, patients referred for ET must be able to perform either treadmill or bicycle exercise.

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Cardiogenic Shock Related to Valvular Heart DiseaseAcute or chronic dysfunction of native or prosthetic valves may cause cardiogenic shock and should be considered in its differential diagnosis (Tables 1 and 2). In the SHOCK trial registry ., of 1190 patients with cardiogenic shock, 8% suffered from a pre-existing severe valvular disease, which caused or worsened their hemodynamic status.

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iPSC-Derived Micro-Heart Muscle for Medium-Throughput Pharmacology and Pharmacogenomic Studies,Micro-heart muscle arrays enable medium-throughput experiments to model the cardiac response to a variety of environmental and pharmaceutical effects. Here, we describe stem cell culture maintenance, methods for successful cardiac differentiation, and formation of micro-heart muscle arrays for electrophysiology and molecular biology assays.

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Aneurysmal Disease of the Ascending Aorta, Root, and Arch,The aortic root, ascending aorta and arch are subject to degenerative changes as well as familial and inherited conditions which can predispose to aneurysm formation. Surgical intervention is warranted to prevent aneurysm rupture or to manage its acute aortic syndromes.

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,A Report on Artin’s Holomorphy Conjecture,The purpose of this paper is to present a report on the current status of Artin’s holomorphy conjecture. For a fascinating account of how Artin was led to defining his .-series and his ‘reciprocity law’ see [19].