Titlebook: Biopharmaceutics Applications in Drug Development; Rajesh Krishna,Lawrence Yu Book 2008 Springer-Verlag US 2008 absorption.bioequivalence.

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978-1-4419-4434-4Springer-Verlag US 2008

CONE

Rajesh Krishna,Lawrence Yudiscusses state of the art knowledge in biopharmaceutics.identifies key issues and opportunities in a distinct problem-solving approach

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Molecular and Physicochemical Properties Impacting OralAbsorptionofDrugs,ase of compliance, and cost-effectiveness. Not surprisingly, desirable oral bioavailability is one of the most important considerations for the successful development of bioactive molecules. Poor oral bioavailability affects drug performance and leads to high intra- and inter-patient variability.

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performance is a vital aspect of new drug development as it draws on interdisciplinary expertise from both pharmaceutics and pharmacokinetics disciplines. It is at the key interface that the discipline of biopharmaceutics has emerged. The past two decades have witnessed considerable advances in bio

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H. J. K?lsch,P. Rairoux,J. P. Wolf,L. W?stefulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requirements and do have the GRAS (generally regarded as safe, a system used by the US FDA) status when used in those amounts which are normally used to fabricate a drug delivery system.

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Excipients as Absorption Enhancers,fulfill the same safety profile as a drug with the exception that it should not exert a therapeutic effect. Most excipients do comply with these requirements and do have the GRAS (generally regarded as safe, a system used by the US FDA) status when used in those amounts which are normally used to fabricate a drug delivery system.

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