Titlebook: Biomedical Aspects of Drug Targeting; Vladimir Muzykantov,Vladimir Torchilin Book 2002 Springer Science+Business Media New York 2002 Epoxi

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Tumor Necrosis Treatment and Imaging of Solid Tumorsed in our laboratory. Tumor Necrosis Therapy (TNT) represents a radical departure from current methods that employ monoclonal antibodies (MAbs) to bind to tumor-associated cell surface antigens and require the use of different antibodies for each type of tumor. In contrast, TNT is based upon the hyp

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Targeted Apoptosis: Antibodies Linked to RNA Damaging Agentswhich new drugs can be designed. For small molecule drugs, the focus is on interfering with molecular targets that contribute to deregulated cell growth and signaling pathways, predominantly within the cancer cell. Antigens aberrantly expressed on the cancer cell surface also afford possible valid m

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Rüdiger Esser,Elisabeth FeldmarLarge-scale studies with mortality endpoints comparing fibrinolytic therapy with placebo in patients with acute myocardial infarction (AMI) have documented the benefit of timely dissolution of coronary arterial thrombi by intravenous infusion of plasminogen activators (Fig. 1).(1)

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Thrombus Targeting of Plasminogen Activators and AnticoagulantsLarge-scale studies with mortality endpoints comparing fibrinolytic therapy with placebo in patients with acute myocardial infarction (AMI) have documented the benefit of timely dissolution of coronary arterial thrombi by intravenous infusion of plasminogen activators (Fig. 1).(1)

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The Most Interesting City in Austriaormidable challenges. Drug targeting strategies have to traverse diverse barriers: biological (e.g., associated with drug delivery, subcellular addressing of a drug, metabolization of carriers, etc), technological (e.g., associated with production, dosing, shelf-life of a drug-carrier complexes) and