Titlebook: Biomedical Aspects of Drug Targeting; Vladimir Muzykantov,Vladimir Torchilin Book 2002 Springer Science+Business Media New York 2002 Epoxi

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Strategies and Means for Drug Targeting: An Overviewcal processes or with defective biological pathways, but not on its selective accumulation in the specific intracellular compartment or in the target cell, organ or tissue. Traditional pharmaceutical agents, practically independent of the administration route, distribute evenly (or at least proporti

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Targeting Atherosclerotic Plaquesvascular ultrasound (3) can demonstrate the precise location of the lesions, the extent of luminal narrowing and plaque thickening. However, both methods are invasive and cannot provide the composition or the metabolic status of the atherosclerotic lesion (4). Plaques rich in macrophages and foam ce

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Tissue-Specific Pharmacodelivery and Overcoming Key Cell Barriers in Vivo: Vascular Targeting of Cavssays that screen for pharmacological actions on the cell type of interest are frequently used in the design of new drugs. Although the potential for such agents is great and certainly justified by their success in vitro, they frequently perform much less effectively in vivo where the agent must rea

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Intravascular Re-Targeting of Viral Vectorstially envisaged as a strategy to correct inherited genetic disorders, the approach has been substantially broadened to encompass the use of gene-based therapies for a variety of acquired diseases. In essence, the approach involves the delivery of nucleic acids (i.e. genes) into cells whereupon the

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