Titlebook: Biomechanics in Oncology; Cheng Dong,Nastaran Zahir,Konstantinos Konstantopo Book 2018 Springer Nature Switzerland AG 2018 Biomaterials in

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Exposing Cell-Itary Confinement: Understanding the Mechanisms of Confined Single Cell Migration,s, and extracellular matrix. The molecular machinery that cells utilize to migrate through confining pores or microtracks shares both similarities and differences with that used in unconfined 2D migration. Depending on the exact properties of the local microenvironment and cell contractile state, ce

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Engineered Models of Metastasis with Application to Study Cancer Biomechanics,ional monolayer cultures cannot recapitulate the complex microenvironment and chemical and mechanical cues that tumor cells experience during their metastatic journey, nor the complexity of their interactions with other, noncancerous cells. As alternative approaches, various engineered models have b

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Biomechanics of the Circulating Tumor Cell Microenvironment, and exposed to the immune system and hemodynamic forces leading to the conclusion that life as a CTC is “nasty, brutish, and short.” While there is much evidence to support this assertion, the mechanisms underlying this are much less clear. In this chapter we will specifically focus on biomechanica

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Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer,ther increasing or decreasing stiffness is associated with aggressive disease. This chapter discusses this controversy in more detail, but the fact that tumor stiffening plays a key role in cancer progression and in regulating cancer cell behaviors is clear. The impact of having . biomaterial system

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Traction Force Microscopy for Noninvasive Imaging of Cell Forces,copy is a noninvasive technique that enables the in vitro imaging and quantification of cell forces. Utilizing expertise from a variety of disciplines, recent developments in traction force microscopy are enhancing the study of cell forces in physiologically relevant model systems, and hold promise

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Noninvasive Imaging: Brillouin Confocal Microscopy, and pathology. Recognizing this importance, Brillouin spectroscopy instrumentation, already utilized in physics and material science, has been adopted for cell and tissue biomechanics. For biomedical applications, progress of Brillouin spectrometer technology has been crucial, mainly improvement in