Titlebook: Biomarkers of the Tumor Microenvironment; Lars A. Akslen,Randolph S. Watnick Textbook 2022Latest edition The Editor(s) (if applicable) and

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Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironmentson, intravasation, extravasation, and outgrowth at the metastatic site. While the tumor reprogrammed BM cells constitute attractive targets for anti-cancer therapy, recent studies have also begun to unravel their role as prognostic and predictive molecular markers of the disease..In this chapter, we

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The Role of Platelets in the Tumor Microenvironmenteillance, and function as long-distance cargo carriers that transmit signals between primary tumors, metastases, and the bone marrow. Platelets have also been reported to have anti-cancer functions by supporting tumor blood vessel normalization and containing anti-angiogenic factors. Therefore, a ke

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The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistancesioned, but rather AXL is involved in regulating cancer cell plasticity related to the EMT program. This new knowledge has provided a framework to understand the role of AXL-mediated signal transduction in cancer. Accordingly, a growing number of studies have demonstrated that AXL signaling is requi

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https://doi.org/10.1007/978-3-658-36125-9endothelial cells. We list key experimental and clinical studies that discuss the clinical relevance of specific molecular markers in predicting prognosis and therapy response, supporting the importance of tumor-associated angiogenesis in pathological processes such as metastasis. In addition to thi

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https://doi.org/10.1007/978-3-658-36125-9ion of an immune tolerance, which may explain why high lymphatic vessel density is often associated with poor prognosis. Therefore, it is likely that lymphatic vessels play multiple complex roles at different stages of cancer development, and that the research on the impact of lymphatics on cancer w

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Epistemologie des Postfaktischen,cantly impacts tumor growth and progression. These two properties add to the complexity of tumor-stroma interactions and have significant implications for gene regulation, matrix remodeling, and tumor metastasis. The role of the tumor stroma is thus extremely complex and highlights the importance of

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https://doi.org/10.1007/978-3-642-48039-3nter-case variability and emerging explorative studies indicate potential for development of PDGFRs as biomarkers of clinical utility. Furthermore, PDGFR-beta-specific targeting remains a valid topic for future therapeutic studies that should be performed in selected patient populations.