Titlebook: Biomarkers of Human Aging; Alexey Moskalev Book 2019 Springer Nature Switzerland AG 2019 Aging.Biomarker.Genome.Epigenome.Immunosenescence

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https://doi.org/10.1007/b138840iabetes, cardiovascular diseases, Alzheimer’s or Parkinson’s). In other words, aging biomarkers are indicators of a preclinical stage of father aging-related pathologies. Interventions should reverse these biomarkers to a younger state or slow down their changes with aging.

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Konstruieren sicherheitsgerechter Produktecuss several basic considerations when modeling biological age. Finally, we highlight some biomarker candidates with the highest application potentials, including epigenome, microRNAs especially exosome microRNAs, and recently developed image-based phenome and microbiome markers.

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Introduction,iabetes, cardiovascular diseases, Alzheimer’s or Parkinson’s). In other words, aging biomarkers are indicators of a preclinical stage of father aging-related pathologies. Interventions should reverse these biomarkers to a younger state or slow down their changes with aging.

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Practical Detection of Biological Age: Why It Is not a Trivial Taskicians, who would successfully combine data-driven and knowledge-based approaches, and the biologists who would be instrumental in critically evaluating insights generated in silico and ensure a discernible biological rationale for the metrics of biological age.

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Epigenomic, Transcriptome and Image-Based Biomarkers of Agingcuss several basic considerations when modeling biological age. Finally, we highlight some biomarker candidates with the highest application potentials, including epigenome, microRNAs especially exosome microRNAs, and recently developed image-based phenome and microbiome markers.

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Genetic Markers of Extreme Human Longevitytrols, the effect of population structure and assortative mating. We then discuss the important contributions to the genetics of extreme human longevity of the last few years that have arisen from genome-wide association studies and the work that is needed to discover additional longevity genes.

Commonwealth

DNA Methylation Markers to Assess Biological Age the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for development of the clocks.