Titlebook: Biomarkers in Neoplastic Neuropathology; Fausto Rodriguez,Cheng-Ying Ho Book 2016 Springer International Publishing Switzerland 2016 Brain

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Biomarkers Applied to Specific Tumor Types,ncer Genome Atlas have started to clarify the basic drivers in the major tumors involving the nervous system. Major biomarkers that have been widely accepted in the area of diffuse gliomas include . promoter methylation, . mutations, and 1p19q co-deletion that have become standard of care for molecu

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Fausto Rodriguez,Cheng-Ying HoDescribes the techniques available for clinical and experimental evaluation of biomarkers in brain neoplasms.Discusses the diagnostic, prognostic, and predictive biomarkers applicable to specific tumo

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https://doi.org/10.1007/978-3-662-02087-6earch settings. Immunohistochemistry and in situ hybridization have been particularly applied in routing diagnostic settings, given their early optimization to formalin-fixed paraffin-embedded tissues, and the preservation of tumor and tissue morphology. Other robust techniques including array-based

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https://doi.org/10.1007/978-3-662-02087-6nning, resources, and active involvement of neuropathology. Samples stored for neoplastic neuropathology in particular include snap-frozen and formalin-fixed paraffin-embedded (FFPE) tissues, as well as cerebrospinal fluid (CSF), blood, and saliva for biomarker discovery and nonneoplastic DNA contro