Titlebook: Biomarker Methods in Drug Discovery and Development; Feng Wang Book 2008 Humana Press 2008 Clinical sample handling.DNA.Drug efficacy and

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Schlussbemerkungen und Ausblick,the clinic of targeted therapeutics. This unprecedented opportunity to perform measures of human physiology responding to pharmacologic intervention requires an understanding of sample collection, handling (preanalytical variables), and assay qualification for the results to be informative and allow

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Christian D. Middel,Patrick R. Staehlel conditions. Once these gene expression “signatures” have been elucidated, they can be used in screening assays to identify compounds that induce similar gene expression changes. To increase the throughput of these screening assays, we have optimized the development of a fluorescent microsphere–bas

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https://doi.org/10.1007/978-3-662-08149-5creasingly important role in all phases of drug development as well as regulatory decision making. However, translating biomarker discovery into clinically useful tests in a time- and cost-effective manner remains a significant challenge. Real-time polymerase chain reaction (PCR) technology, in part

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Softwarestruktur eines Funktionsblocks,sequencing is a genotyping assay based on sequencing by synthesis. Short runs of sequence around each polymorphism are generated, allowing for internal controls for each sample. Pyrosequencing can also be used to identify triallelic, indel, and short-repeat polymorphisms, as well as determining alle

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