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Titlebook: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates; W. E. G. Müller,H. C. Schr?der Book 1994 Sprin

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發(fā)表于 2025-3-21 17:20:30 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates
影響因子2023W. E. G. Müller,H. C. Schr?der
視頻videohttp://file.papertrans.cn/188/187453/187453.mp4
學(xué)科分類Progress in Molecular and Subcellular Biology
圖書(shū)封面Titlebook: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates;  W. E. G. Müller,H. C. Schr?der Book 1994 Sprin
影響因子Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2‘,5‘-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
Pindex Book 1994
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Klinisch angewandte Immunologieosenthal 1988) and the inhibition of glycosylation by prostaglandin A (Santoro et al. 1989) or 2-deoxyglucose (Blough and Ray 1980). However, if the virus is not killed, such a strategy can lead to the development of a drug-resistant virus (Field and Goldthorpe 1989).
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Double-Stranded RNAs as Gene Activators,f dsRNA are achieved through activation of a defined set of genes (O’Malley et al. 1979; Stewart 1979; De Maeyer and De Maeyer-Guignard 1988; Haines et al. 1991). As a consequence, cells synthesize new proteins that change their growth capacity and modulate their functions.
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,Chemical Synthesis of 2′,5′-0ligoadenylate Analogues,heir antiviral properties (Sehgal et al. 1983), the inhibition of cell growth, the inhibition of tumor cell proliferation, their augmentation of natural killer (NK) activity, the modulation of immune response, the interaction of nuclear formation and the delay of cells entering into S-phase of the cell cycle (Suhadolnik et al. 1983).
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發(fā)表于 2025-3-22 17:44:26 | 只看該作者
,2′,5′-0ligoadenylate Synthetase in Autoimmune BB Rats,n the destructive process, but the triggering event still remains elusive. In the many attempts to understand the etiopathogenesis of IDDM great help has come from different animal models like the streptozotocin-treated mice, the NOD (nonobese diabetic) mice, and the spontaneously diabetic BB rat.
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發(fā)表于 2025-3-23 00:59:53 | 只看該作者
0079-6484 also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.978-3-642-78551-1978-3-642-78549-8Series ISSN 0079-6484 Series E-ISSN 2197-8484
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