Titlebook: Biological Reactive Intermediates Vi; Chemical and Biologi Patrick M. Dansette,Robert Snyder,I. Glenn Sipes Book 2001 The Editor(s) (if app

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Harness

Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/s. This includes the quinones/quinone methides of catechol-type metabolites from estrogens and polycyclic aromatic hydrocarbons.. Metabolic activation of estrogens to redox active and/or electrophilic metabolites has been proposed as one of the mechanisms responsible for the link between estrogen ex

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Structure Toxicity Relationships - How Useful Are They in Predicting Toxicities of New Drugs?, of severe toxic effects. Although in some cases the parent drug structure may be responsible for the observed toxicities, in most cases reactive metabolites are formed that interact with cellular macromolecules to stress cells directly, and/or more commonly, yield immunogenic products. Since it is

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New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde,uces altered liver cell foci, neoplastic nodules, and hepatocellular carcinoma upon oral administration to F344 rats (Chung et al, 1986; IARC, 1995). Acetaldehyde causes tumors of the respiratory tract in rats and hamsters upon exposure by inhalation (IARC, 1985; 1999). Crotonaldehyde and acetaldehy

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Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Modcan produce premature ovarian failure (early menopause in women) because once destroyed, they cannot be replaced. Menopause is known to be associated with an increased incidence of a variety of health problems such as osteoporosis, cardiovascular disease, and ovarian cancer. Exposure of women to che

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