Titlebook: Biological Reactive Intermediates III; Mechanisms of Action James J. Kocsis,David J. Jollow,Robert Snyder Book 1986 The Editor(s) (if appli

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Ulrich Bathmann,Victor Smetacekesis, carcinogenesis, and other cytotoxicities (Mitchell et al., 1976; Boyd, 1980; Wright, 1980; Miller and Miller, 1981, 1982; Boyd and Statham, 1983). It is also evident, however, that xenobiotics that are biotransformed into reactive metabolites usually exert relatively selective toxic effects wi

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https://doi.org/10.1007/978-3-642-57807-6 P-450 by forming stable complex with the Iron of the hemoporphyrin. Several derivatives of erythromycin having lost their cladinose moiety are stronger inducer of liver cytochrome P-450 itself. The major form of cytochrome P-450 induced by all these macrolides in rat liver electrophoretically and i

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Klima?nderungen und Klimaschwankungenonating their intact 4-alkyl group to one of the pyrrole nitrogens of haem in hepatic cytochrome P-450 (De Matteis et al., 1981; Ortiz de Montellano et al., 1981; Tephly et al., 1981). Because of the asymmetrical arrangement of the two vinyl and propionate side chains in protoporphyrin IX, four stru

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,Hypothalamic–Pituitary Axis Function,rious electrophiles. In addition, the transferases bind with high affinity various exogenous hydrophobic compounds as well as potentially toxic endogenous compounds such as bilirubin and heme (1–3). The enzymes are comprised of binary combinations of at least six major subunits, Yα, Ya, Ybl, Yb2, Yc

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A. Barbarino,L. De Marinis,A. Manciniially hydrolyzed by the microsomal form, while .-stilbene oxide is the prefered substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of SpragueDawley (outbred strain) liver cytosolic epoxide hydrolase were observed, varying from 2 to 77 pmol/min x mg

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https://doi.org/10.1007/978-3-662-36245-7e apparent that benzene can also be leukemogenic (Snyder, 1984). Benzene-induced bone marrow depression is caused by one or more metabolites of benzene (Snyder, et al., 1981). Cytochrane P-450 mediates the first step in benzene metabolism (Gonasun et al., 1973). The initial metabolite formed in the