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Titlebook: Biological Reactive Intermediates; Formation, Toxicity, David J. Jollow,James J. Kocsis,Thomas Walle Book 1977 Springer Science+Business Me

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發(fā)表于 2025-3-21 17:54:20 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Biological Reactive Intermediates
期刊簡稱Formation, Toxicity,
影響因子2023David J. Jollow,James J. Kocsis,Thomas Walle
視頻videohttp://file.papertrans.cn/188/187439/187439.mp4
圖書封面Titlebook: Biological Reactive Intermediates; Formation, Toxicity, David J. Jollow,James J. Kocsis,Thomas Walle Book 1977 Springer Science+Business Me
影響因子The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a
Pindex Book 1977
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Mechanism of Microsomal Monooxygenases and Drug Toxicityug may cause an activation of another drug which could result in cell damage or even cancer. Therefore, the booming research in drug metabolism during the last two decades has also provided the knowledge for our understanding of drug toxicity.
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https://doi.org/10.1007/978-3-658-19515-1e intermediates. These epoxide intermediates in turn undergo enzymatic reactions mediated by epoxide hydrase or glutathione-.-epoxide transferase, or are non-enzymatically converted to various hydroxylated products. Epoxides also react irreversibly with cellular components (2).
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Introduction to the Concept of Reactive Intermediatestes may be the cause of serious forms of toxicity including cellular necrosis, mutagenesis, carcinogenesis, teratogenesis, hypersensitivity, and blood disorders such as hemolytic anemia, blood dyscrasias, and methemoglobinemia.
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Discussiona fundamental component of the fetal liver. In contrast, the lack of P450 in the fetus of common laboratory animals suggests that they may not require the ability to metabolize steroids during fetal life.
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