Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press

ALTER

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https://doi.org/10.1007/978-3-322-99428-8 include other tumors and genes (Hoffman, 1984). Finally, dietary deprivation of the methyl donors methionine and choline had been shown to induce liver carcinomas in rats (Copeland and Salmon, 1946). Although these findings were accepted for a period of nearly 10 years, the subsequent demonstration

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https://doi.org/10.1007/978-3-662-66619-7e 28 S rRNA and present in the large subunit of eukaryotic (but not of prokaryotic) ribosomes, contains two 2′?0 methylated ribose residues (Nazar .., 1975a, b ; MacKay and Doolittle, 1981 ; Schnare and Gray, 1982). Whereas phosphodiester bonds adjacent to methylated bases in RNA display normal sens

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https://doi.org/10.1007/978-90-313-7590-5of these enzymes would function as components of reversible covalent modification systems to regulate the activity of various methyl-accepting proteins (Gagnon and Heisler, 1979; Paik and Kim, 1980; O’Dea et al., 1981). Although this does appear to be the case for a class of bacterial methyltransfer

Stricture

Kleine ontwikkelingspsychologie IIbeen well established (Paik & Kim, 1980). It involves N-methylation of lysine, arginine, histidine, alanine, proline, and glutamine, O-methylation of glutamic and aspartic acid, and S-methylation of methionine and cysteine (Paik & Kim, 1985). As shown in Table I, methylated amino acids occur in high

Magnificent

Kleine ontwikkelingspsychologie II role of this enzyme are 1) the nature and specificity of relevant . protein substrates; 2) the stoichiometry of protein carboxylmethylation and 3) the rapid hydrolysis of carboxylmethylesters under conditions of neutral and basic pH (Billingsley and Lovenberg, 1985). Thus, two major schools of thou

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geriatrician

Kinetic

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