Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press

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Tissue Specific DNA Methylation Patterns: Biochemistry of Formation and Possible Rolec expression have been studied in the past 8 years with respect to their methylation pattern (for recent review, see Razin and Szyf, 1984). Investigators took advantage of the restriction enzymes HpaII (CCGG) and HhaI (GCGC) that are inactive when the internal cytosine residue in their recognition s

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Regulation of Gene Expression by Site-Specific Promoter Methylationtter et al., 1978; Eick et al., 1983). Even the DNA of a symmetric recombinant (Deuring et al., 1981; Deuring & Doerfler, 1983) between the left terminus of adenovirus type 12 DNA and large amounts of human cell DNA, which was encapsidated into virus particles, was not methylated (Deuring et al., 19

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Relationship Between Methylation and Maturation of Ribosomal RNA in Prokaryotic and Eukaryotic Cells1 % of the total number) (Attardi and Amaldi, 1970 ; Hall, 1971), but the distribution of methyl groups in prokaryotic and eukaryotic ribosomal RNAs is strikingly different (see Table 1 of Maden, 1976 and Table 1 of Bj?rk, 1983). . 16 S and 23 S rRNAs contain a small number of 2′?0 methylated ribose

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Distribution of m6A in mRNA and its Possible Biological Roleethylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 1975), the function of internal methylation of specific adenine residues, to form N.-methyladenosine (m.A), is not clear. It has been suggested that m.A serves some nuclear role in precursor processing and

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Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U

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Regulation of Phospholipid Methylation by Reversible Phosphorylation). Phospholipid methyltransferase has now been purified some 300-fold from rat liver (Pajares et al., 1983). The purified enzyme is activated by incubation with ATP and the catalytic subunit of cyclic AMP dependent protein kinase (cAMP-PK) (Varela et al., 1984). Under these conditions, only one prot

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Brain Phosphatidylcholine Pools as Possible Sources of Free Choline for Acetylcholine Synthesis choline-containing compounds (like PC) ., and liberate free choline from these larger molecules. Secondly, when labelled choline was infused intravenously into rats, specific radioactivities of free choline in the brain were found to be lower than those in the blood or liver, suggesting that unlabe