Titlebook: Biological Mechanisms of Minimal Residual Disease and Systemic Cancer; Julio A.‘Aguirre-Ghiso Book 2018 Springer Nature Switzerland AG 201

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https://doi.org/10.1007/978-3-658-18524-4uantitatively assess residual disease and accurately prognosticate PFS and OS in myeloma. In this chapter, we will discuss the current techniques for MRD detection as well as describe techniques that are emerging for improved characterization of drug resistant residual populations that could be adap

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0065-2598 . ??..?..This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, 978-3-319-97746-1Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Biological Mechanisms of Minimal Residual Disease and Systemic Cancer

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Preservation of Quiescent Chronic Myelogenous Leukemia Stem Cells by the Bone Marrow Microenvironmelated to tyrosine kinase independent mechanisms which include intrinsic properties of LSCs determined by epigenetic alterations, altered transcriptional regulatory networks or mitochondrial/metabolic changes. In addition to cell intrinsic changes, signals from the bone marrow microenvironment (BMM)

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Minimal Residual Disease in Multiple Myeloma: Impact on Response Assessment, Prognosis and Tumor Heuantitatively assess residual disease and accurately prognosticate PFS and OS in myeloma. In this chapter, we will discuss the current techniques for MRD detection as well as describe techniques that are emerging for improved characterization of drug resistant residual populations that could be adap

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Auf das Nerven system wirken de Stoffe,ion, anti-angiogenic agents were expected to suppress the growth of any type of primary or metastatic tumor, independent of their subtype or genetic landscape. However, more that 20?years after the first anti-angiogenic preclinical trial, the astonishing inhibition of metastatic outgrowth originally

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