Titlebook: Biological Markers of Alzheimer’s Disease; Fran?ois Boller,Robert Katzman,Yves Christen Conference proceedings 1989 Springer-Verlag Berlin

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,Altered Protein Kinase and Amyloid ?-Protein Precursor in Alzheimer’s Disease: Which Comes First?,dystrophic neuntes, collectively referred to as NP. NP are specific to AD, whereas NFT are found in many other neurodegenerative diseases. The purpose of this report is to present a hypothesis regarding the biochemical basis for these pathologic features of AD — neurodegeneration and NFT and NP form

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,The Amyloid Gene of Alzheimer’s Disease and Neuronal Dysfunction,t al. 1985). The major constituent of these depositions is a protein that is now commonly termed the β A4 protein, according to its proposed secondary structure of beta pleated sheets and its relative molecular weight of 4 kDa. Protein sequencing of amyloid from brains of patients with AD as well as

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