Titlebook: Biological Effects of Fibrous and Particulate Substances; Takemi Otsuki,Yasuo Yoshioka,Andrij Holian Book 2016 The Editor(s) (if applicabl

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Macrophage and Multinucleated Giant Cell Classification,d in this chapter depends on the pathway of activation. The third major section focuses on multinucleated giant cells, which are formed by fusion of individual macrophages. The ontogeny of each subset will be discussed and the current literature regarding particulate/foreign-body interaction will be

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NLRP3 Inflammasome-Mediated Toxicity of Fibrous Particles, particles. In addition, the review demonstrates the potential mechanism of IL-1β secretion through the NLRP3 inflammasome, with a focus on the role of the GTPase effector Rho kinases (ROCK1 and 2), which are known to be involved in a wide range of cellular functions including adhesion, regulation o

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Health Effects of Silver Nanoparticles and Silver Ions,in (MT)-bound form was related in cellular behavior and toxicity of AgNPs and AgNO.. The cytotoxic effect of AgNPs is a simple function of neither the number nor total surface area. Although the effect may vary among the cell types and the culture conditions, AgNPs were transported to lysosomes and

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Silicates and Autoimmunity,produce collagen. Silica particles are enveloped by collagen leading to fibrosis and nodular lesions. These findings are consistent with an autoimmune pathogenesis that begins with activation of the innate immune system leading to proinflammatory cytokine production, inflammation of the lung leading

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