Titlebook: Biological Barriers to Protein Delivery; Kenneth L. Audus,Thomas J. Raub Book 1993 Springer Science+Business Media New York 1993 biochemis

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https://doi.org/10.1007/978-3-662-32847-7ne-releasing transdermal therapeutic system (Transderm-Scop? by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin-releasing systems. Currently, about ten drugs have been either successfully marketed or are under clinical evaluation for transdermal delivery.

Tracheotomy

Intraoral Peptide Absorptiont especially for small- or medium-size peptide drugs. Potential advantages for intraoral delivery are the avoidance of gastrointestinal or liver first-pass effect, the feasibility of locally controlled absorption enhancement, the ease of administration and removal of an administered device, and the sustainment of drug action.

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Dermal Absorption of Peptides and Proteinsne-releasing transdermal therapeutic system (Transderm-Scop? by Ciba) for motion sickness. This was followed by the marketing of several nitroglycerin-releasing systems. Currently, about ten drugs have been either successfully marketed or are under clinical evaluation for transdermal delivery.

deviate

The Immune System as a Barrier to Delivery of Protein Therapeutics another species and has a different amino acid sequence, or it may be perceived as foreign due to a more subtle difference, such as being denatured or aggregated. Low-molecular-weight drugs generally do not initiate an immune reaction unless they become conjugated to protein, as occasionally occurs with penicillin.

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Historische und moderne Rahmenbedingungen,ons (e.g., the frog skin, the colon mucosa, the kidney collecting tubule), the TJ is in fact very restrictive and the amount of substances flowing through the paracellular pathway is almost negligible. On the contrary, in epithelia separating two compartments with similar ionic composition, and that

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Entwicklungstrends von Familien,nfeld and Mellman, 1989). The pH optima of many of these enzymes are less than 5 (for reviews see Barrett and McDonald, 1980; McDonald and Barrett, 1986) consistent with their acting in lysosomes, whose pH is in this vicinity (Ohkuma and Poole, 1978). However, some enzymes have a higher pH optimum,

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Der frühe A. S. Neill in Gro?britannienintestine to function as a gatekeeper. In addition to controlling transepithelial transport of proteins from the lumen to the interstitial tissue of the mucosa, the intestinal epithelium fulfills other roles such as digestion and absorption of nutrients and maintenance of a functional barrier.

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https://doi.org/10.1007/978-3-662-32847-7., 1988) are being investigated for peptide and protein delivery. Among these routes, rectal and vaginal are potentially important routes for peptide administration, although they are poorly accepted in several countries. In contrast to the oral route, the rectal delivery of peptide/protein drugs pr

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