Titlebook: Biochemistry of the Eye; Elaine R. Berman Book 1991 Springer Science+Business Media New York 1991 biochemistry.eye.ophthalmology.retina

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Selected Topics in Biochemistry Relevant to the Eye,d to serve as background for Chapters 2 through 7. The material in the first section on cellular biochemistry is based almost entirely on several general texts (Lehninger, 1982; Darnell .., 1986; Stryer, 1988; Alberts .., 1989). For the remaining sections, additional source material is cited when relevant.

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Tears,e ocular surface and nutrients for the corneal epithelium (Bron, 1985; Lamberts, 1987a). The tear film also serves as a vehicle for the entry of PMNs (polymorphonuclear leukocytes) in case of injury and dilutes and washes away toxic irritants from the ocular surface.

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Peter Osterrieder,Stefan Richtercompartment surrounded by epithelial (lens, ciliary body) and neuroglial (retinal Müller cells) cells which form basal laminae around it” (Balazs and Denlinger, 1984). Further studies at the molecular level are clearly needed to reconcile these differing points of view.

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Lens,ion on the evolution and origins of the lens crystallins. Equally intensive efforts are being directed toward biochemical characterization of the lens fibers and elucidation of the role played by the gap junction-like protein, MP26 (main intrinsic polypeptide of . . 26,000), in cell-to-cell communication.

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Retina,whose fibers extend from the vitreous surface (or inner limiting “membrane” of the retina) to beyond the outer limiting “membrane,” where they surround the photoreceptor inner segments. In histological cross section, the neural retina is organized into ten distinct layers, including the pigment epithelium, as described in the legend to Fig. 7.1.

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Cornea, avascular tissue, the nutritional needs of the cornea are met by the tear film (the source of atmospheric oxygen) and the aqueous humor (the major source of glucose) (Stanifer .., 1983; Maurice, 1984; Friend, 1987).