Titlebook: Biochemistry and Genetics of Recq-Helicases; David B. Lombard Book 2001 Springer Science+Business Media New York 2001 DNA.Mutation.Nucleos

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Targeting the WRN Locus in the mouse,nd encodes a novel member of the RecQ DNA helicase family. Here the cloning of a highly conserved murine homolog of WRN, mWRN, is described. Unlike the human WRN protein, which is concentrated in the nucleolus, mWRN is distributed throughout the nucleus. Mice lacking the mWRN protein are viable and

噴油井

Interaction of the BLM protein with Topo III alpha in Somatic and meiotic cells,cQ family. Sgslp, a RecQ-family helicase in . interacts physically and functionally with the topoisomerase III protein. Using coimmunoprecipitation and immunolocalization, we demonstrate in somatic human cells an association between BLM and the topoisomerase Topo III alpha and between Topo III alpha

Axillary

Nijmegen Breakage Syndrome disease protein and Mre11 at PML Nuclear Bodies and meiotic telomeres,ty to cancer. The gene product defective in NBS, p95, associates with two other proteins, Mre11 and Rad50, and these proteins form foci following irradiation (termed IRIFs). Here we demonstrate that in the absence of DNA damage, a portion of p95 and Mre11 is concentrated in PML Nuclear Bodies (NBs);

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Book 2001ns in a newlycharacterized RecQ-family member, RECQ4, may lead to the very rarerecessive disorder Rothmund-Thomson syndrome, a conditioncharacterized by developmental abnormalities and some aging-likemanifestations. This book is intended for any researchers invested inthese particular disorders, or

ADJ

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Anticoagulants

Targeting the WRN Locus in the mouse,se..Some of the mouse data in this chapter has been previously published: Lombard DB, Beard C, Johnson B . (2000): Mutations in the WRN gene in mice accelerate mortality in a p53-null background. . 20:3286–3291. Used by permission..The immunofluorescence presented in this chapter has been previously

Spirometry

Interaction of the BLM protein with Topo III alpha in Somatic and meiotic cells,ologous chromosomes. Thus the genome instability observed in BS may involve perturbations in the activities of DNA topoisomerases, in addition to defects in BLM itself..This chapter is a modified version of a manuscript representing an equal contribution between Brad Johnson and myself. Much of the

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