Titlebook: Bioactive Sphingolipids in Cancer Biology and Therapy; Yusuf A. Hannun,Chiara Luberto,Lina Marie Obeid Book 2015 Springer International Pu

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Ian C. W. Hardy,Daniel R. Smithr bioactive role in apoptosis and differentiation. Ever since, hematological malignancies have represented a powerful model to discover and dissect sphingolipid-related functions in the context of cell proliferation, differentiation, autophagy, immunological responses and neoplastic transformation.

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https://doi.org/10.1007/978-3-031-23880-2 has been put into developing a thorough understanding of the molecular and genetic events that contribute to tumor progression due to mounting evidence that breast cancers are driven by predictable and identifiable genetic mutations, Sphingolipids modulate many of the growth, apoptosis, inflammator

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Clavius and Mathematics in the ,, of cancer death and consequently has become a significant public health problem worldwide in fair-skinned populations. The discovery of the prevalent mutation BRAFV600E, which drives melanoma cell growth, has made this oncogenic protein an ideal therapeutic target. However, the beneficial effects o

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New Transculturalisms, 1400–1800ountries. Although recent studies provide knowledge of the molecular signaling pathways that are implicated in colon carcinogenesis, treatments and outcomes still need further improvement. Bioactive sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate (S1P), are signaling molecu

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https://doi.org/10.1007/978-981-99-2464-6ely, current therapy is inefficient and advanced HCC is highly resistant to chemotherapy, making early diagnosis crucial for survival. HCC develops in the course of chronic liver disease and inflammation. Progressive non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease

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https://doi.org/10.1007/978-981-99-2464-6e ceramide, the aliphatic backbone of sphingolipids, can act as a powerful tumor censor; a favorable attribute. However, cancer cells are equipped to efficiently inactivate ceramide via various metabolic routes: glycosylation to form glucosylceramide, and hydrolysis, which generates sphingosine and

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Jesus in an Age of Enlightenmentn addition to being important for membrane structures. With the identification of enzymes involved in metabolism of various bioactive molecules of the sphingolipid pathway, a better and broader understanding has been gained of how cells control signaling events, such as proliferation and apoptosis,