Titlebook: Bioactive Lipids in Health and Disease; Andres Trostchansky,Homero Rubbo Book 2019 Springer Nature Switzerland AG 2019 Arachidonic acid.in

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Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Acti ligand-activated transcription factors. A variety of lipophilic molecules, including long-chain polyunsaturated fatty acids and eicosanoids, are capable of binding to PPAR, although the nature of the physiological ligands is still under debate. PPARs regulate the expression of a set of genes involv

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Diminishing Inflammation by Reducing Oxidant Generation: Nitrated Fatty Acid-Mediated Inactivation omatory oxidants and secondary nitrating species. Electrophilic nitrated fatty acid derivatives, such as nitro-oleic acid (OA-NO.) are also noted to display a broad spectrum of anti-inflammatory effects via interaction with critical signaling pathways. An alternative process in which nitrated fatty a

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Unfolded Protein Response: Cause or Consequence of Lipid and Lipoprotein Metabolism Disturbances?, under excess macronutrient uptake, those pathways overcharge nucleus-to-endoplasmic reticulum (ER) traffic pathways, leading to luminal overload of unfolded proteins which activates a series of adaptive signaling pathways known as unfolded protein response (UPR). The UPR is a central network mecha

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Arachidonic Acid and Nitroarachidonic: Effects on NADPH Oxidase Activityophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation. NOX2 is the enzyme responsible for a huge superoxide formation in macrophages, essential to eliminate pathogens inside the phagosome. The oxidase is an enzymatic complex comprised of a membrane–bound flavocytochrome .. (gp91./p22.

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Epicardial Adipose Tissue in Cardiovascular Diseaselarization strategies. Obesity, also accompanied by a chronic inflammatory process, is an independent risk factor for CVD. Abdominal adipose tissue is a complex, metabolically very active organ capable of producing different adipokines and hormones, responsible for endocrine-metabolic comorbidities.

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