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Titlebook: Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease; Hoa Huu Phuc Nguyen,M. Angela Cenci Book 2015 The Editor(s) (if a

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發(fā)表于 2025-3-21 17:36:18 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease
影響因子2023Hoa Huu Phuc Nguyen,M. Angela Cenci
視頻videohttp://file.papertrans.cn/183/182860/182860.mp4
發(fā)行地址Gives an overview of the clinical aspects of Huntington’s Disease (HD) and Parkinson’s Disease (PD) and reviews the construct, face and predictive validity of animal models.Provides information on whi
學(xué)科分類Current Topics in Behavioral Neurosciences
圖書封面Titlebook: Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease;  Hoa Huu Phuc Nguyen,M. Angela Cenci Book 2015 The Editor(s) (if a
影響因子Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Pindex Book 2015
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書目名稱Behavioral Neurobiology of Huntington‘s Disease and Parkinson‘s Disease影響因子(影響力)




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沙發(fā)
發(fā)表于 2025-3-21 23:50:06 | 只看該作者
Current Topics in Behavioral Neuroscienceshttp://image.papertrans.cn/b/image/182860.jpg
板凳
發(fā)表于 2025-3-22 02:49:23 | 只看該作者
https://doi.org/10.1007/978-3-662-46344-4Huntington; LRRK2; Parkin; Pink-1; Polyglutamine; animal models
地板
發(fā)表于 2025-3-22 05:03:05 | 只看該作者
5#
發(fā)表于 2025-3-22 11:56:15 | 只看該作者
,Transgenic Rat Models of Huntington’s Disease,vel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.
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發(fā)表于 2025-3-22 16:39:04 | 只看該作者
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發(fā)表于 2025-3-22 17:16:19 | 只看該作者
Additional Insights From the Surveyvel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.
8#
發(fā)表于 2025-3-23 00:52:09 | 只看該作者
https://doi.org/10.1007/978-3-319-28591-7ms. Symptoms progress over 15–20?years, and there are currently no disease-modifying therapies. The causative genetic mutation is an expanded CAG repeat in the . gene encoding the Huntingtin protein, and is inherited in an autosomal dominant manner. In this chapter we discuss the genetics, clinical
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發(fā)表于 2025-3-23 02:55:11 | 只看該作者
Alexander Jokisch,Wilhelm Urban,Thomas Klugens of the brain. Therefore, the striatum which is preferentially degenerated and receives projections from the entire cortex also affects the regions to which it targets, especially the globus pallidus and substantia nigra pars reticulata. Additionally, the cerebral cortex is itself severely affecte
10#
發(fā)表于 2025-3-23 06:39:19 | 只看該作者
https://doi.org/10.1007/978-3-319-28591-7erative disorder. Its occurrence through generations of affected families was noted long before the basic genetic underpinnings of hereditary diseases was understood. The early classification of HD as a distinct hereditary neurodegenerative disorder allowed the study of this disease to lead the way
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