Titlebook: Bayesian Adaptive Design for Immunotherapy and Targeted Therapy; Haitao Pan,Ying Yuan Book 2023 Springer Nature Singapore Pte Ltd. 2023 Ad

值得

https://doi.org/10.1007/978-90-481-9667-8method (CRM), modified toxicity probability interval design (mTPI), Keyboard design, and Bayesian optimal interval design (BOIN). Characteristics of these designs are explained and contrasted. Unique challenges of using phase I trials for immunotherapies and targeted therapies are described.

尾巴

Confirm

Scintillations

FID

嫌惡

Phase I Designs for?Late-Onset Toxicitychapter introduces three model-based designs, including the time-to-event CRM (TITE-CRM), fractional CRM (fCRM), data augmentation CRM (DA-CRM), and a model-assisted design, i.e., time-to-event BOIN (TITE-BOIN), to deal with late-onset toxicity. Trial examples and software are provided to demonstrate the implementation of designs.

表狀態(tài)

Optimal Biological Dose and?Phase I/II Trials appropriate to identify the optimal biological dose (OBD) that optimizes the risk-benefit tradeoff of the treatment, rather than the maximum tolerated dose (MTD). This chapter reviews basic concepts of the OBD and the phase I/II design paradigm to find the OBD.

Hallmark

Model-Based Designs for?Identification of?Optimal Biological Dose-toxicity and dose-efficacy model, and continuously update the estimate of the model in a way similar to the continual reassessment method (CRM). The model estimate is then used to guide dose escalation/de-escalation. Herein, the software of these designs is introduced.

BACLE

https://doi.org/10.1007/978-3-031-05871-4 U-BOIN have the advantages of being simple to implement and meanwhile yielding competitive performances. Conducting the trial does not require complicated model estimation. The decision of dose transition can be easily made by looking up the pre-generated decision table. Examples and software are provided to illustrate BOIN12 and U-BOIN.

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