Titlebook: Axon Growth and Guidance; Dominique Bagnard Book 2007 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer

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Eph Receptors and Ephrin Ligands in Axon Guidance,l line) make up the largest family of receptor tyrosine kinases. In vertebrates, 14 Eph receptor members have been identified, divided in two sub-groups, the EphAs (EphA1 to A8) and EphBs (EphB1 to B6). Their nine membrane-bound ligands, the ephrins, are also subdivided into the ephrin-As (ephrin-A1

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Slits and Their Receptors,al nervous system by midline glia cells .–.. Slit homologues have since been found in .. and many vertebrate species, from amphibians, . fishes, . birds .–. to mammals ..–.. A single . was isolated in invertebrates, whereas there are three . genes (.) in mammals, that have around 60% homology .. All

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,The Hedgehog, TGF-β/BMP and Wnt Families of Morphogens in Axon Guidance,ate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules and suggest that these proteins, rather than having sharply divergent functions, act more globally

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