Titlebook: Applied Physiology to Reduce Ventilator Induced Lung Injury; Clinical Application Gary F. Nieman,Nader M. Habashi Book 2024 The Editor(s) (

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978-3-031-66354-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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Gary F. Nieman,Nader M. HabashiExplores the mechanisms of ventilator induced lung injury (VILI) in the microenvironment and how to minimize it.Translates the latest basic science research into clinical practice.Identifies innovativ

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Elizabeth C. Oesterle,Jennifer S. Stonery linked to an unacceptably high mortality rate. The primary treatment approach involves essential supportive measures, predominantly relying on mechanical ventilation. Despite decades of investigation, challenges such as the complexities of lung involvement, diverse responses to interventions, and

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https://doi.org/10.1007/b138721ss syndrome (ARDS) involves reducing tidal volume (V.) and plateau pressure (Pplat) while adjusting the fraction of inspired oxygen (FiO.) and positive end-expiratory pressure (PEEP) using the ARDSnet low V. (LV.) method (The Acute Respiratory Distress Syndrome Network, N Engl J Med 342:1301–8, 2000

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https://doi.org/10.1007/b138721 with a functioning surfactant system, results in a very stable homogeneous inflation pattern (Chap. .). In the acutely injured lung, loss of these stabilizing factors renders the lung time- and pressure-dependent, meaning it will take more time for alveoli to open and less time for them to collapse

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