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Titlebook: Autoimmunity and the Pathogenesis of Diabetes; Fredda Ginsberg-Fellner (Professor of Pediatrics, Book 1990 Springer-Verlag New York Inc.

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期刊全稱Autoimmunity and the Pathogenesis of Diabetes
影響因子2023Fredda Ginsberg-Fellner (Professor of Pediatrics,
視頻videohttp://file.papertrans.cn/167/166160/166160.mp4
學(xué)科分類Endocrinology and Metabolism
圖書封面Titlebook: Autoimmunity and the Pathogenesis of Diabetes;  Fredda Ginsberg-Fellner (Professor of Pediatrics,  Book 1990 Springer-Verlag New York Inc.
影響因子It has been a challenge for us to edit this volume of Endocrinology and Metabo- lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des- truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the p
Pindex Book 1990
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The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens,-cell autoantibodies were detected by indirect immunofluorescence on a substrate of unfixed, fresh frozen, human pancreas sections. Since this initial demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circula
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The Pathogenesis of Immunologically Mediated Diabetes,y over the last 60 years, and it is probably fair to say that we still do not understand the physiologic trigger for the process that leads to insulin-dependent (type I) diabetes nor the detailed mechanisms of beta-cell destruction. This lack of detailed knowledge is no reason to shy away from the s
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Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus,anisms governing transmission of the diabetes trait still is not well understood. Concordance for insulin-dependent diabetes mellitus (IDDM) between identical twins approaches 50%, suggesting that nongenetic influences, such as environmental factors, contribute to the clinical expression of a geneti
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