Titlebook: Atypical Elements in Drug Design; Jacob Schwarz Book 2016 Springer International Publishing Switzerland 2016 Drug Design.Silicon Mimics.Un

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1862-2461 eractionson the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known g978-3-319-80205-3978-3-319-27742-4Series ISSN 1862-2461 Series E-ISSN 1862-247X

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David J. Briggs,Pip Forer,Richard Sterns, and the pharmacokinetics. Examples resulting from the carbon/silicon switch strategy are sila-venlafaxine, sila-haloperidol, and disila-bexarotene, the silicon analogues of the serotonin/noradrenaline reuptake inhibitor venlafaxine, the dopamine antagonist haloperidol, and the retinoid agonist be

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Mandy Y. F. Tang,Cheong-wai Tsoiast, a significant number of promising efforts are underway that are aimed at designing and developing pharmaceutical agents that are selenium-based or that target specific aspects of selenium metabolism. This chapter focuses on some of these efforts to develop new selenium-based anticancer, antioxi

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GIS for Health and the Environmentajor threats to bio-macromolecules, such as DNAs, RNAs, proteins, lipids, and carbohydrates. They may cause molecular oxidation and DNA damage/mutation, alter gene expression patterns, weaken the immune system, and even lead to neurological disorders and other pathological conditions. As potential d

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Drug Design Based on the Carbon/Silicon Switch Strategy,s, and the pharmacokinetics. Examples resulting from the carbon/silicon switch strategy are sila-venlafaxine, sila-haloperidol, and disila-bexarotene, the silicon analogues of the serotonin/noradrenaline reuptake inhibitor venlafaxine, the dopamine antagonist haloperidol, and the retinoid agonist be

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Selenium-Functionalized Molecules (SeFMs) as Potential Drugs and Nutritional Supplements,ajor threats to bio-macromolecules, such as DNAs, RNAs, proteins, lipids, and carbohydrates. They may cause molecular oxidation and DNA damage/mutation, alter gene expression patterns, weaken the immune system, and even lead to neurological disorders and other pathological conditions. As potential d

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