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Titlebook: Atypical Antipsychotics; Bart A. Ellenbroek,Alexander R. Cools Book 2000 Springer Basel AG 2000 dopamine.research.schizophrenia.serotonin.

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發(fā)表于 2025-3-21 18:43:21 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Atypical Antipsychotics
影響因子2023Bart A. Ellenbroek,Alexander R. Cools
視頻videohttp://file.papertrans.cn/165/164936/164936.mp4
學(xué)科分類Milestones in Drug Therapy
圖書封面Titlebook: Atypical Antipsychotics;  Bart A. Ellenbroek,Alexander R. Cools Book 2000 Springer Basel AG 2000 dopamine.research.schizophrenia.serotonin.
影響因子The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill- ness, it allowed, for the first time, to adequately control the severe hallu- cinations and delusional beliefs which prevent these patients from leading a more or less independent life. Indeed these antipsychotics (and the many congeners that were to follow) significantly reduced the number ofchronic schizophrenic inpatients in psychiatric clinics all over the world. However soon after their introduction it became clear that, like all other available drugs, antipsychotics were by no means miracle drugs. In fact, two major problems appeared. First, the antipsychotics had very little effect on the so-called negative or defect symptoms, like social isolation, apathy and anhedonia, and secondly virtually all antipsychotics produced a number of side-effects, of which the neurological (often called extra- pyramidal) side-effects were the most troublesome. Especially the tardive dyskinesia, which occurred in about 15 to 20% of the patients after pro- longed treatment
Pindex Book 2000
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發(fā)表于 2025-3-21 23:47:59 | 只看該作者
From first to second generation antipsychoticschotic drugs that had been available for some three decades or more, most commonly perphenazine and haloperidol, with an additional 2% receiving loxapine and 13% receiving clozapine [.]. Since the identification in the 1950s of chlorpromazine as the archetype antipsychotic, a profound advance that h
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發(fā)表于 2025-3-22 02:31:07 | 只看該作者
Animal models for schizophrenia: an introductionn identified. The main reason for this, apart from the difficulties in diagnosis (see Liddle, this volume), is the limited accessibility of the human brain. Until about 20 years ago, the investigation of the brains of patients was limited to.analysis. This technique (with a high spatial resolution)
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發(fā)表于 2025-3-22 05:19:16 | 只看該作者
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發(fā)表于 2025-3-22 12:43:13 | 只看該作者
Regional selectivity of antipsychotic drugsfficacy, the incidence of side-effects (especially the extrapyramidal side-effects) differs between individual drugs. This has already been known for a long time, but the earlier studies were largely overlooked. Among the earlier papers were a number of clinical studies comparing several phenothiazi
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發(fā)表于 2025-3-22 14:21:25 | 只看該作者
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發(fā)表于 2025-3-22 20:15:38 | 只看該作者
Simulation models for schizophreniast decade through the recognition that not only symptoms, but also psychophysiological and psychological disturbances of the disease can be used. This has led to the development of models like prepulse inhibition (PPI), P50 gating and latent inhibition. However, the development of models simulating
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發(fā)表于 2025-3-23 00:38:37 | 只看該作者
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發(fā)表于 2025-3-23 04:52:44 | 只看該作者
Dopamine receptor subtypes and schizophrenia: a clinical perspectiveal infections with viruses [.], structural abnormalities in the brain [..], receptor dysfunctions in many neurotransmission or transduction systems [..]. Concerning the latter the dopaminergic system has been implicated in schizophrenia for more than four decades. Whereas in early studies the metabo
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發(fā)表于 2025-3-23 05:46:08 | 只看該作者
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