Titlebook: Arenaviruses II; The Molecular Pathog Michael B. A. Oldstone Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Contribution of LCMV Transgenic Models to Understanding T Lymphocyte Development, Activation, Toleruestions and others have been addressed in many models, including murine TCR transgenic systems, in which the transgenic expression of TCR chains provides a clonal population of antigen-specific T cells that can be readily monitored.

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Bystander T Cell Activation and Attrition, are essential to this process, due to their ability to differentiate between self and non-self antigens presented by class I major histocompatibility antigens (MHC I) found on the surface of the majority of nucleated cells (. 1999; . 1999; . and . 1999). Virus-specific CD8 T cells that encounter vi

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Immunocytotherapy,ber of the arenaviridae family, has become an important tool to evaluate the feasibility and efficacy of therapeutic immune cell grafting. Subsequent mechanistic and quantitative studies (. et al. 1986; . et al. 1987; . and . 1988; . et al. 1995; . et al. 1997; . et al. 2000) have established the LC

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Mechanisms of Humoral Immunity Explored Through Studies of LCMV Infection,strate immunological memory. For years, long-term antibody production was attributed solely to the continuous stimulation and differentiation of memory B cells into antibody-secreting plasma cells. However, several studies have now revealed that long-lived plasma cells, most of which reside in the b

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Regulation of Virally Induced Autoimmunity and Immunopathology: Contribution of LCMV Transgenic Modn systems. Second, as discussed in this chapter, the anti-viral immune response can be harmful, in contrast and addition to its beneficial effect of eliminating or decreasing the viral load. For example, cytokines and chemokines secreted by cells and other components of the immune system can have de