Titlebook: Arenaviruses I; The Epidemiology, Mo Michael B. A. Oldstone Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive lice

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Lassa Fever,that arenaviruses have co-evolved along with their rodent hosts over a time scale of as much as 9 million years. Among six arenaviruses so far known to cause human illness, only one, Lassa virus, is from Africa. Three other arenaviruses have been isolated in Africa: Mopeia virus from . in southern A

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Arenaviruses: Genomic RNAs, Transcription, and Replication,quence information (for extensively referenced reviews see . et al. 1980; .-. 1984; . 1986; . 1993a; . 1996). There is some variability in the lengths of the genomic RNA segments for individual arenaviruses (L approximately 7,200 bases, S approximately 3,400 bases), but the general organization of t

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Arenaviruses: Protein Structure and Function,etic plan, these viruses are capable of interacting with the host in a bewildering variety of permutations that result in a range of infections from a lifelong persistent carrier state, as is evident in the neonatally or congenitally infected carrier mouse, to the lethal acute diseases typical of La

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Expeditionary Forces in the First World Warvative diagnostic resource, together with a specific RT-PCR assay for LCMV (. et al. 1997), should have a significant positive impact on the rapid recognition and characterization of new arenavirus infections.

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