| 期刊全稱 | Approaching Complex Diseases | | 期刊簡稱 | Network-Based Pharma | | 影響因子2023 | Mariano Bizzarri | | 視頻video | http://file.papertrans.cn/161/160338/160338.mp4 | | 發(fā)行地址 | The first book to systematically cover the issue of how to integrate network biology, systems biology and polypharmacology.The only book dealing with the proposal of a paradigm shift in drug discovery | | 學(xué)科分類 | Human Perspectives in Health Sciences and Technology | | 圖書封面 |  | | 影響因子 | .This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biol | | Pindex | Book 2020 |
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