Titlebook: Apolipoproteins in Lipid Disorders; Risk Assessment and Maryvonne Rosseneu,Kurt Widhalm,Jochen Jarausch Book 1991 Springer-Verlag/Wien 199

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Clinical significance of apolipoprotein measurements,ipidemia, where apolipoprotein profiles are altered in a significant way. The concentration of apolipoprotein B is increased in various types of primary and secondary dyslipidemia including: Type II, III and V primary dyslipidemia, chronic renal failure and Type I, insulin-dependent diabetes. Apo AI

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Apolipoproteins and coronary heart disease, familial studies. Recent studies investigated the value of apolipoprotein measurements in the assessment of coronary hard disease risk. Most of the studies indicate that apo AI and B are strong CHD risk predictors. Apo B seems to be more strongly associated with cardiovascular risk than LDL-C or HD

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Apolipoproteins AI and B in health and metabolic disease,ith type II diabetes, 25 with hypertension, 23 with hypercholesterolemia and 21 with hypertriglyceridemia. When compared to the nephelometric reference method, both apo AI and apo B showed excellent correlation coefficients (0.99). A good correlation was also found for both apo AI vs HDL-cholesterol

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The clinical relevance of apolipoprotein determination,ipid metabolism. Apolipoproteins AI and B are very stable parameters which can be determined with high precision. If one could agree on one method for determination of apo B or establish a central laboratory, the determination of apo B in dried blood-spots for screening purposes is desirable. By thi

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Development of reagents for apolipoproteins AI and B designed for automated routine determination,mmunoturbidimetric technique. Several typical properties of turbidimetry and the resulting potential for optimization are discussed. The development of a special enhancer detergent mix leads to rapid, reproducible assays with a two-week calibration stability and excellent performance data.

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Results from a European multicentre evaluation of immunoturbidimetric assays for apolipoproteins AIthe precipitin reaction between apolipoproteins and specific anti-apolipoprotein antibodies at 340 nm. The measurements with the new reagents were performed on BM/Hitachi 704/717 and COBAS. Mira analysers. In method comparison with automated routine assays, a reasonable comparability was obtained wi

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Standardization of apolipoprotein measurements, of assays. Such problems include: lack of primary standards with certified values, method-to-method variation, lack of comparability for sample treatment, etc..International organizations including: the International Union of Immunological Societies (I.U.I.S.), the International Federation of Clini

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