Titlebook: Anxiolytics; Mike Briley,David Nutt Book 2000 Springer Basel AG 2000 brain.development.drug.drugs.feeling.future.peptides.pharmaceutical.p

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Book 2000mal tests developed since the 1960s have been optimised for the benzodiazepines and some programmes have even screened candidates as potential anxiolytics on their benzodiazepine-like side-effects rather than their anxiolytic activity. With the realisation of the drawbacks of the benzodiazepines, na

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The benzodiazepines: a brief review of pharmacology and therapeutics, nucleus benzo-1, 4-diazepine structure. One compound, chlordiazepoxide (Fig. 1), exhibited sedative, anticonvulsant and muscle relaxant properties, which were confirmed by clinical studies and was launched as an anxiolytic in 1960 under the trade name Librium. A second compound, diazepam (valium),

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Monoamine oxidase inhibitors (including the newer reversible compounds),lts in changes in cerebral function. Monoamine oxidase metabolizes and thus inactivates endogenous pressor amines (like serotonin and noradrenaline) as well as ingested amines absorbed from the gut (like tyramine). The therapeutic effect of MAOIs is supposed to be linked to an inhibition of the degr

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Selective serotonin re-uptake inhibitors in anxiety disorders: room for improvement,m and long-term treatment. The efficacy of SSRIs is similar to that of tricyclic antidepressants (TCAs) in patients with major depression, apart from in the subgroup of hospitalised in-patients, where TCAs are marginally, but significantly, more effective [.]. In randomised controlled trials, the to

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