Titlebook: Anxiolytic β-Carbolines; From Molecular Biolo David N. Stephens Book 1993 Springer-Verlag Berlin Heidelberg 1993 Beta Carboline.GABA.anxiet

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MIRTH

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,Abecarnil: A New ?-Carboline Anxiolytic Preliminary Clinical Pharmacology,mmisse and Hayes 1987). However, their depressant effects on the central nervous system (CNS), expressed as sedation, ataxia and often amnesia, as well as their dependence potential after long-term use, often complicate the course of the treatment.

松雞

exclusice

,Station?re elektrische Felder,epine receptor (BZ receptor). Although this compound was not the endogenous ligand but an artifact of the isolation procedure, it was considered a promising lead for the development of psychotropic drugs acting via the BZ receptor because of the following features:

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撫育

Elektrische und magnetische Felder mid-1980s all members of this pharmacological class were of a very similar nature chemically all being [1,4] benzodiazepine molecules (except clordiazepoxide, Fig. 1). Surprisingly, all new compounds discovered for almost three decades with the characteristic diazepam-like anxiolytic, hypnotic, and

cogitate

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陰謀

Elektrische und magnetische Feldere thought to assemble to form individual chloride-channel complexes bearing GABA. receptors and their associated modulatory sites. Five distinct subunit classes, some containing several isoforms (α., β., γ., 5 and ρ.) encoded by separate genes, have been identified by molecular cloning (see e.g., Ol