Titlebook: Antisense Therapeutics; Sudhir Agrawal Book 19961st edition Humana Press 1996

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Antisense Efficacy,viding important insights into their roles in tumorigenesis or normal growth and development (.–.). Although attention has been focused recently on the development of antisense ODN as therapeutics for a variety of diseases, including cancer (.), systemic application of ODN to treat tumors other than

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Antisense Tumor Therapy,toncogenes (.). The imphcation is that the targets that must be attacked in neoplastic cells are normal cellular genes that have sustained some activating lesion. The . family of mammalian proto-oncogenes includes three members, termed Ha-., Ki-., and N-., that are found to be activated very often i

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Antisense Inhibition of Protein Synthesis and Function,human diseases, a major problem is that most extracellular compartments are constantly mixing with the blood, lymph, cerebrospinal fluid (CSF), and so forth, and thus constantly diluting the oligonucleotide. A possibly unique exception to this problem is the vitreous, a gelatinous fluid overlying th

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c-, in Smooth Muscle Cells, vn-us (AMV) and E26 leukemia virus (.). The . gene is highly conserved in eukaryotes, and it usually consists of 15 exons spanning over 35 kb of genomic DNA (.).In humans, . gene locus has been mapped to chromosome 6 (6q22-23) However, . mRNA expressed in thymus contains transcripts originating fro

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Antisense-Mediated Inhibition of Protein Synthesis,ics. The specrficlty of the hybridization reaction and the surprisingly efficient uptake of synthetrc oligonucleotide derivatives provide a new class of selective protein synthesis inhibitors. Concurrently with the development of the antisense technology, elucidation of the pathogenetic role of mdrv

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