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Titlebook: Antineoplastic and Immunosuppressive Agents; Part I Alan C. Sartorelli (Professor),David G. Johns Book 1974 Springer-Verlag Berlin · Heidel

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0171-2004 at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through- out the world. At t978-3-642-65680-4978-3-642-65678-1Series ISSN 0171-2004 Series E-ISSN 1865-0325
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Agents of Choice in Neoplastic Diseaseug — a body of knowledge that is evolving rather dynamically. This chapter is written with the objective of providing a general framework for the detailed discussions to follow, so that the reader, should he have the need, may find an orientation to current usage of antitumor drugs. With this in min
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Rational Design of Alkylating Agentsing cells, and testicular and ovarian tissues are also damaged. The cancer chemotherapist has the problem of modifying the structure of the so-called biological alkylating agents in such a way as to render them specifically cytotoxic towards neoplastic tissue.
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Site of Action of Cytotoxic Agents in the Cell Life Cycle to the problem of designing treatment schedules for malignant disease (.. et al., 1965; ., 1965; . et al., 1967; ., 1968; for example) spurred much research towards defining which agents exert their lethal effect at which phase of the cell generation cycle, that is in .., ., .., or . as defined in
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The Constancy of the Product of Concentration and Timeighting reflex was restored. Similar observations with respect to brain levels were made in rats and guinea pigs, and in all four species serum levels were a reflection of brain drug levels. He also reported that carisoprodol had a 10-fold spread in duration of action in various animal species, but
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