Titlebook: Antimutagenesis and Anticarcinogenesis Mechanisms III; Giorgio Bronzetti,Hikoya Hayatsu,Claire Wilson & A Book 1993 Springer Science+Busin

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Multiple Mechanisms: The Example of Vitamin Ashown to be prevented by retinoids, which in this organ function as antitumor promoters in the two-stage system using 7,12-dimethylbenz(a)anthracene (DMBA) as the initiator, and 12-tetradecanoyl-phorboll3-acetate (TPA) as tumor promoter. Even though pharmacological doses applied topically appear to

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Protective Mechanisms of Dietary Fibers in Nutritional Carcinogenesis action in carcinogenesis, classification into two broad types, soluble and insoluble fibers, is warranted. Soluble fibers are present in fruits, vegetables, and certain grains like oats. This type of fiber undergoes metabolism in the small intestine and especially in the large intestine through bac

Congestion

Extracellular Interception of Mutagenss of defense against chemical mutagens/carcinogens. Kada and Shimoi (25) have classified molecules that function in this manner as “desmutagens,” and many of them are natural cellular metabolites (23). Among the specific mechanisms that such agents may employ are: prevention of the activation of “pr

Glucose

Proteins as Scavengers of Nitrite: Antimutagenic Implicationsproduced from arginine in mammalian cells (9). Several epidemiological studies demonstrated that there is a good correlation between nitrate intake and gastric cancer mortality (4). It has been shown that various mutagenic or carcinogenic compounds are produced from food components by reactions with

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Extrapolation of in Vitro Antimutagenicity to the in Vivo Situation: The Case for Anthraflavic Acid Ames Salmonella/microsome test as the biological endpoint. Various plant compounds or extracts are incorporated into the postmitochondrial (S9) activation system and their ability to inhibit the mutagenicity of model precarcinogens is determined. However, such a protocol suffers from a number of ma

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