Titlebook: Antimicrobial Resistance; A Crisis in Health C Donald L. Jungkind,Joel E. Mortensen,Gary B. Calan Book 1995 The Editor(s) (if applicable) a

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0065-2598 cribed. Today it is an uncommon event for a clinical laboratory to isolate an S. aureus that is sensitive to penicillin. Other gram-positive strains of bacteria978-1-4757-9205-8978-1-4757-9203-4Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Lumped-Driven Method for Motion Controllopment of resistance on the part of some fungal pathogens. From amphotericin B we have expanded to multiple new classes of drugs, with multiple alternatives within those classes. However, we have still not reached the optimal agents which are fungicidal, minimally toxic, and can be administered eit

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Book 1995Shortly after the widespread introduction of penicillin in the early 1940s, the first strains of penicillin-resistant staphylococci were described. Today it is an uncommon event for a clinical laboratory to isolate an S. aureus that is sensitive to penicillin. Other gram-positive strains of bacteria

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Donald L. Jungkind,Joel E. Mortensen,Gary B. Calan

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Introduction to Integrated Opticss agent. These include prevention of intracellular drug accumulation, alteration in the target of the drug, and production of a drug-inactivating enzyme. The relative importance of each of these mechanisms varies depending upon the organism involved, the antimicrobial agent, and the location of the

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S. K. Kurtz,S. D. Kozikowski,L. J. Wolframs 2 and 3 (figure 1). Imipenem, the first commercially-available carbapenem, (Merck Sharp and Dohme) has been used for nearly 10 years and is now being joined by a second agent, meropenem (Zeneca/Sumitomo). The development of a third carbapenem, biapenem (Lederle) has recently been discontinued. In

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