Titlebook: Antifolate Drugs in Cancer Therapy; Ann L. Jackman Book 1999 Springer Science+Business Media New York 1999 biochemistry.cancer.cancer ther

RUPT

C. Guillén,M. C. Romero,I. Galindoriority to evaluate drugs that may possess either greater efficacy or activity in tumors with intrinsic or acquired resistance to established treatment. Nolatrexed dihydrochloride (Thymitaq.) is a novel folate-based inhibitor of thymidylate synthase (TS). TS is the rate-limiting enzyme in the . bios

Connotation

https://doi.org/10.1007/978-3-031-35135-8nce DNA synthesis, has been achieved with a range of quinazoline analogs of folic acid, including CB3717 (.–.) and its non-nephrotoxic successor, Tomudex. (ZD1694, raltitrexed) (.–.). The latter compound has recently been introduced in a number of counties for the treatment of advanced colorectal ca

Rejuvenate

Flat-Feet

C. Guillén,M. C. Romero,I. Galindo glycinamide ribonucleotide formyltransferase (GARFT). Lometrexol was a landmark anticancer compound for a number of reasons: it was the first potent and selective GARFT inhibitor, it had in vivo antitumor activity in models in which earlier classes of antifolate drugs were inactive (.) and it was,

preeclampsia

Javier Dóniz-Páez,Rafael Becerra-Ramírezidylate, purines, and amino acids (.).For this reason, cellular folate homeostasis depends on the delivery of reduced folate cofactors from extracellular fluids. At a physiological pH, the negatively charged α- and γ-carboxyl groups of the glutamate side chain of reduced folate cofactors change thes

placebo-effect

https://doi.org/10.1007/978-3-031-07289-5in hematopoietic cells and intestinal mucosa, with lesser effects on kidney, liver, and the central nervous system (.). An accepted strategy to overcome these toxicities is the supplementation of folates as rescue agents (.–.). In this context, the use of high doses of methotrexate (MTX) with leucov

禁止

Disaster Studies and Management, methionine, purines, and thymidylate. Across the phylogenetic spectrum, intracellular folates consist almost entirely of poly (γ-glutamyl) metabolites (Fig. 1; reviewed in refs. .–.). A distribution of lengths generally occurs that is cell type-specific; within a given source the distribution is g

前兆

Asim Zia,Mujahid Hussain,Kashif Hameedcally in the late 1960s, in diseases such as leukemia and lymphoma. The basic principle in selection of these combinations was simple; drugs that were effective as single agents but had nonoverlapping normal tissue toxicity were chosen (e.g., vincristine and prednisone). If drugs had similar toxicit

maverick

Asim Zia,Mujahid Hussain,Kashif Hameedacil remains one of the most active agents in the treatment of diseases such as colorectal, breast, and head and neck cancer. Attempts to biomodulate the activity of 5-fluorouracil have focused primarily on enhancing its ability to inhibit the target enzyme thymidylate synthase which is essential fo

Epithelium