Titlebook: Antiepileptic Drugs and Pregnancy; A Guide for Prescrib MJ Eadie,FJE Vajda Book 2016 Springer International Publishing Switzerland 2016 Ant

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有法律效應(yīng)

不開心

Antiepileptic Drug Disposition in Pregnancy and placenta at the time of childbirth, have consequences for the body’s handling of drugs. The physiological changes have little effect on the absorption of the orally administered drugs, but the expanded extracellular fluid volume of pregnancy and the increasing bulk of the uterus and its content

思考

The Older Antiepileptic Drugsn used in pregnancy, to provide a background to considering the alterations pregnancy and its aftermath produce in these parameters. The four drugs considered, viz. phenobarbitone, phenytoin, carbamazepine and valproate, are cleared from the body mainly by virtue of metabolism, and the clearance val

尊嚴(yán)

Commonly Used Newer Antiepileptic Drugsn pregnant women, viz. lamotrigine, topiramate and levetiracetam. There is more information available for the first of these drugs than for the other two. The clearance value for lamotrigine, which is almost fully biotransformed to glucuronides, is considerably increased during pregnancy, with the c

狂亂

寒冷

小丑

Antiepileptic Drugs and Foetal Malformations: A Possible Class Effectopment of foetal malformations. The occurrence of such malformations is relatively uncommon, and it has taken time and the accumulation of moderately sized data collections before the following information has emerged, viz.

HILAR

泰然自若

Antiepileptic Drugs, Cognition and Neurodevelopmentt trimester of human pregnancy may be associated with the occurrence of physical malformations in the foetus but, in addition, foetal valproate exposure poses a significant risk for the cognitive development of the infant, an effect that is dose dependent. Carbamazepine and lamotrigine exposures app