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Titlebook: Antiepileptic Drugs; Pharmacology and The Mervyn J. Eadie,Frank J. E. Vajda Book 1999 Springer-Verlag Berlin Heidelberg 1999 catecholamines

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發(fā)表于 2025-3-21 19:47:09 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Antiepileptic Drugs
期刊簡(jiǎn)稱Pharmacology and The
影響因子2023Mervyn J. Eadie,Frank J. E. Vajda
視頻videohttp://file.papertrans.cn/159/158543/158543.mp4
發(fā)行地址Includes supplementary material:
學(xué)科分類Handbook of Experimental Pharmacology
圖書封面Titlebook: Antiepileptic Drugs; Pharmacology and The Mervyn J. Eadie,Frank J. E. Vajda Book 1999 Springer-Verlag Berlin Heidelberg 1999 catecholamines
影響因子In 1985, volume 74 of the Springer-Verlag Handbook of Experimental Phar- macology, under the editorship of H. -H. Frey and D. Janz, appeared. In this volume the then available data on the topic of antiepileptic drugs were col- lated and analysed. Over the intervening years knowledge in this area has grown progressively. More new antiepileptic drugs than the total number of agents that were in common use 15 years ago have in the interval either come on to the market or are about to do so. As well, further agents are at a fairly advanced stage of development, whilst the already established drugs have by and large held their places in clinical practice. Knowledge of epileptogenesis has advanced considerably. The mechanisms of action of antiepileptic drugs at the molecular level and in various animal models of epileptic seizures and of the epileptic state are much better understood than they were previously. As well, more information is available concerning the natural history of human epilepsy, and this knowledge is important in making optimal use of the various agents that are now available. Therefore, it has seemed appropriate at this stage in the evolution of knowledge to produce a
Pindex Book 1999
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https://doi.org/10.1007/978-3-7091-9962-6arbitone and its congeners, the succinimides, sulthiame and acetazolamide, and the bromides. The various oxazolidinediones (principally troxidone — trimetha-dione), formerly important for treating absence epilepsy, now seem to have almost completely disappeared from clinical use, though they are still employed in experimental laboratory studies.
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Werkzeuge für die Werkstoffverarbeitung of action at the molecular level was unclear. The latter has now been elucidated, and considerable additional information has become available concerning the disposition, interactions and toxicity of the drug, mainly in humans, whilst its range of therapeutic uses has expanded. The present chapter deals chiefly with this newer information.
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https://doi.org/10.1007/978-3-662-31601-6ion may be a result of several mechanisms including effects on sodium and potassium channels, a novel interaction with the GABA. receptor and inhibition of the action of kainate on the kainate/AMPA subtype of glutamate receptor.
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Older Anticonvulsants Continuing in Use but with Limited Advance in Knowledge,arbitone and its congeners, the succinimides, sulthiame and acetazolamide, and the bromides. The various oxazolidinediones (principally troxidone — trimetha-dione), formerly important for treating absence epilepsy, now seem to have almost completely disappeared from clinical use, though they are still employed in experimental laboratory studies.
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